Jurkat cells were subjected to SDS PAGE followed by western blot with FNab02083(CUX1 antibody) at dilution of 1:1000
IP Result of anti-CUX1 (IP:FNab02083, 4ug; Detection:FNab02083 1:1000) with mouse brain tissue lysate 4000ug.
Immunohistochemistry of paraffin-embedded mouse brain using FNab02083(CUX1 antibody) at dilution of 1:100
Immunofluorescent analysis of HepG2 cells, using FNab02083(CUX1 antibody) at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).
背景介绍
Probably has a broad role in mammalian development as a repressor of developmentally regulated gene expression. May act by preventing binding of positively-activing CCAAT factors to promoters. Component of nf-munr repressor; binds to the matrix attachment regions(MARs)(5' and 3') of the immunoglobulin heavy chain enhancer. Represses T-cell receptor(TCR) beta enhancer function by binding to MARbeta, an ATC-rich DNA sequence located upstream of the TCR beta enhancer. Binds to the TH enhancer; may require the basic helix-loop-helix protein TCF4 as a coactivator(By similarity).