HeLa cells were subjected to SDS PAGE followed by western blot with FNab03049(FBXO7 antibody) at dilution of 1:1000
IP Result of anti-FBXO7 (IP:FNab03049, 3ug; Detection:FNab03049 1:800) with mouse testis tissue lysate 4000ug.
Immunohistochemistry of paraffin-embedded human prostate cancer using FNab03049(FBXO7 antibody) at dilution of 1:100
背景介绍
Substrate recognition component of a SCF(SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes BIRC2 and DLGAP5. Plays a role downstream of PINK1 in the clearance of damaged mitochondria via selective autophagy(mitophagy) by targeting PARK2 to dysfunctional depolarized mitochondria. Promotes MFN1 ubiquitination.