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HMGB2 antibody
| 规格 | 价格 |
|---|---|
| 100μg | RMB ¥1750 |
| 50μg | RMB ¥1050 |
货期：
三个工作日+顺丰快递时长
- 产品名称
- HMGB2 antibody
- 货号
- FNab03925
- 规格
- 100μg
- 状态
- liquid
- 纯化方法
- Immunogen affinity purified
- 纯度
- ≥95% as determined by SDS-PAGE
- 克隆性
- polyclonal
- 亚型
- IgG
- 存储
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
免疫原信息
- 免疫原
- high-mobility group box 2
- 别称
- High mobility group protein B2|High mobility group protein 2 (HMG-2)|HMGB2|HMG2 antibody
- UniProt ID
- P26583
- 分子量
- 33-35 kDa
验证实验
- 验证实验
- ELISA, WB, IHC, IP
- 建议稀释比例
- WB: 1:500-1:2000; IP: 1:200-1:1000; IHC: 1:20-1:200
验证图片
Jurkat cells were subjected to SDS PAGE followed by western blot with FNab03925(HMGB2 antibody) at dilution of 1:600
IP Result of anti-HMGB2 (IP:FNab03925, 4ug; Detection:FNab03925 1:500) with HEK-293 cells lysate 1200ug.
Immunohistochemistry of paraffin-embedded human brain using FNab03925(HMGB2 antibody) at dilution of 1:100
- 背景介绍
- Multifunctional protein with various roles in different cellular compartments. May act in a redox sensitive manner. In the nucleus is an abundant chromatin-associated non-histone protein involved in transcription, chromatin remodeling and V(D)J recombination and probably other processes. Binds DNA with a preference to non-canonical DNA structures such as single-stranded DNA. Can bent DNA and enhance DNA flexibility by looping thus providing a mechanism to promote activities on various gene promoters by enhancing transcription factor binding and/or bringing distant regulatory sequences into close proximity(PubMed:7797075, PubMed:11909973, PubMed:19522541, PubMed:18413230, PubMed:19965638, PubMed:20123072). Involved in V(D)J recombination by acting as a cofactor of the RAG complex: acts by stimulating cleavage and RAG protein binding at the 23 bp spacer of conserved recombination signal sequences(RSS)(By similarity). Proposed to be involved in the innate immune response to nucleic acids by acting as a promiscuous immunogenic DNA/RNA sensor which cooperates with subsequent discriminative sensing by specific pattern recognition receptors(By similarity). In the extracellular compartment acts as a chemokine. Promotes proliferation and migration of endothelial cells implicating AGER/RAGE(PubMed:19811285). Has antimicrobial activity in gastrointestinal epithelial tissues(PubMed:23877675). Involved in inflammatory response to antigenic stimulus coupled with proinflammatory activity(By similarity). Involved in modulation of neurogenesis probably by regulation of neural stem proliferation(By similarity). Involved in articular cartilage surface maintenance implicating LEF1 and the Wnt/beta-catenin pathway(By similarity).
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