Interferon-induced protein with tetratricopeptide repeats 1 (IFIT-1)|Interferon-induced 56 kDa protein (IFI-56K antibody, P56)|IFIT1|G10P1|IFI56|IFNAI1|ISG56 antibody
货号:
FNab04135
反应性:
Human, Rat, Mouse
宿主:
Rabbit
验证实验:
ELISA, IHC, WB
克隆性:
polyclonal
亚型:
IgG
规格
价格
100μg
RMB ¥2100
50μg
RMB ¥1260
货期:
三个工作日+顺丰快递时长
产品介绍
实验结果
实验条件
常见问题
产品名称
IFIT1 antibody
货号
FNab04135
规格
100μg
状态
liquid
纯化方法
Immunogen affinity purified
纯度
≥95% as determined by SDS-PAGE
克隆性
polyclonal
亚型
IgG
存储
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
免疫原信息
免疫原
interferon-induced protein with tetratricopeptide repeats 1
别称
Interferon-induced protein with tetratricopeptide repeats 1 (IFIT-1)|Interferon-induced 56 kDa protein (IFI-56K antibody, P56)|IFIT1|G10P1|IFI56|IFNAI1|ISG56 antibody
U-937 cells were subjected to SDS PAGE followed by western blot with FNab04135(IFIT1 Antibody) at dilution of 1:600
Immunohistochemistry of paraffin-embedded human breast cancer slide using FNab04135(IFIT1 Antibody) at dilution of 1:50
背景介绍
Interferon-induced antiviral RNA-binding protein that specifically binds single-stranded RNA bearing a 5'-triphosphate group(PPP-RNA), thereby acting as a sensor of viral single-stranded RNAs and inhibiting expression of viral messenger RNAs. Single-stranded PPP-RNAs, which lack 2'-O-methylation of the 5' cap and bear a 5'-triphosphate group instead, are specific from viruses, providing a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection. Directly binds PPP-RNA in a non-sequence-specific manner. Viruses evolved several ways to evade this restriction system such as encoding their own 2'-O-methylase for their mRNAs or by stealing host cap containing the 2'-O-methylation(cap snatching mechanism). Exhibits antiviral activity against several viruses including human papilloma and hepatitis C viruses.