IL23A transfected HEK293 cells were subjected to SDS-PAGE followed by western blot with FNab04256(IL23A monoclonal Antibody) at dilution of 1:1000
Immunohistochemistry of paraffin-embedded human pancreas tissue slide using FNab04256(IL23A Antibody) at dilution of 1:50
背景介绍
Associates with IL12B to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis.