HEK-293 cells were subjected to SDS PAGE followed by western blot with FNab04310(ING2 antibody) at dilution of 1:400
IP Result of anti-ING2 (IP:FNab04310, 3ug; Detection:FNab04310 1:500) with HEK-293 cells lysate 1000ug.
Immunohistochemistry of paraffin-embedded human colon cancer using FNab04310(ING2 antibody) at dilution of 1:50
背景介绍
Seems to be involved in p53/TP53 activation and p53/TP53-dependent apoptotic pathways, probably by enhancing acetylation of p53/TP53. Component of a mSin3A-like corepressor complex, which is probably involved in deacetylation of nucleosomal histones. ING2 activity seems to be modulated by binding to phosphoinositides(PtdInsPs).