HeLa cells were subjected to SDS PAGE followed by western blot with FNab04323(INO80 Antibody) at dilution of 1:600
IP Result of anti-INO80 (IP:FNab04323, 4ug; Detection:FNab04323 1:500) with HeLa cells lysate 2000ug.
背景介绍
DNA helicase and probable main scaffold component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair; according to PubMed:20687897 the contribution to DNA double-strand break repair appears to be largely indirect through transcriptional regulation. Recruited by YY1 to YY1-activated genes, where it acts as an essential coactivator. Binds DNA. In vitro, has double-stranded DNA-dependent ATPase activity. Involved in UV-damage excision repair, DNA replication and chromosome segregation during normal cell division cycle.