K-562 cells were subjected to SDS PAGE followed by western blot with FNab04420(ITPA antibody) at dilution of 1:1000
IP Result of anti-ITPA (IP:FNab04420, 4ug; Detection:FNab04420 1:1000) with mouse liver tissue lysate 4000ug.
Immunohistochemistry of paraffin-embedded human heart tissue slide using FNab04420(ITPA Antibody) at dilution of 1:50
背景介绍
Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate(ITP), deoxyinosine triphosphate(dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate(dHAPTP) and xanthosine 5'-triphosphate(XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy-and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions.