human brain tissue were subjected to SDS PAGE followed by western blot with FNab04488(KCNIP3 antibody) at dilution of 1:500
Immunohistochemistry of paraffin-embedded human gliomas using FNab04488(KCNIP3 antibody) at dilution of 1:50
背景介绍
Calcium-dependent transcriptional repressor that binds to the DRE element of genes including PDYN and FOS. Affinity for DNA is reduced upon binding to calcium and enhanced by binding to magnesium. Seems to be involved in nociception(By similarity). Regulatory subunit of Kv4/D(Shal)-type voltage-gated rapidly inactivating A-type potassium channels, such as KCND2/Kv4.2 and KCND3/Kv4.3. Modulates channel expression at the cell membrane, gating characteristics, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner.
May play a role in the regulation of PSEN2 proteolytic processing and apoptosis. Together with PSEN2 involved in modulation of beta-amyloid formation.