HEK-293 cells were subjected to SDS PAGE followed by western blot with FNab04703(LAS1L antibody) at dilution of 1:1000
IP Result of anti-LAS1L (IP:FNab04703, 4ug; Detection:FNab04703 1:1000) with HEK-293 cells lysate 1200ug.
背景介绍
Involved in the biogenesis of the 60S ribosomal subunit. Required for maturation of the 28S rRNA. Functions as a component of the Five Friends of Methylated CHTOP(5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes.