A549 cells were subjected to SDS PAGE followed by western blot with FNab04947(MAGED1 Antibody) at dilution of 1:1000
Immunohistochemistry of paraffin-embedded human placenta using FNab04947(MAGED1 antibody) at dilution of 1:50
背景介绍
Involved in the apoptotic response after nerve growth factor(NGF) binding in neuronal cells. Inhibits cell cycle progression, and facilitates NGFR-mediated apoptosis. May act as a regulator of the function of DLX family members. May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme(E2) at the E3:substrate complex. Plays a role in the circadian rythm regulation. May act as RORA co-regulator, modulating the expression of core clock genes such as ARNTL/BMAL1 and NFIL3, induced, or NR1D1, repressed.