产品
本公司产品仅供体外研究使用，不用于临床诊断
MMP12 antibody
| 规格 | 价格 |
|---|---|
| 100μg | RMB ¥2100 |
| 50μg | RMB ¥1260 |
货期：
三个工作日+顺丰快递时长
- 产品名称
- MMP12 antibody
- 货号
- FNab05234
- 规格
- 100μg
- 状态
- liquid
- 纯化方法
- Immunogen affinity purified
- 纯度
- ≥95% as determined by SDS-PAGE
- 克隆性
- polyclonal
- 亚型
- IgG
- 存储
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
免疫原信息
- 免疫原
- matrix metallopeptidase 12(macrophage elastase)
- 别称
- Macrophage metalloelastase (MME)|Macrophage elastase (ME antibody, hME)|Matrix metalloproteinase-12 (MMP-12)|MMP12|HME antibody
- UniProt ID
- P39900
- 分子量
- 54 kDa, 45 kDa
验证实验
- 验证实验
- ELISA, WB, IHC, IF
- 建议稀释比例
- WB: 1:500-1:1000; IHC: 1:20-1:200; IF: 1:10-1:100
验证图片
mouse brain tissue were subjected to SDS PAGE followed by western blot with FNab05234(MMP12 Antibody) at dilution of 1:600
Immunohistochemistry of paraffin-embedded human lung cancer tissue slide using FNab05234(MMP12 Antibody) at dilution of 1:50
Immunofluorescent analysis of ( -20℃ Ethanol ) fixed A549 cells using FNab05234 (MMP12 antibody) at dilution of 1:25 and Alexa Fluor 488-conjugated Goat Anti-Rabbit IgG(H+L)
- 背景介绍
- MMP12(Matrix metalloproteinase-12) is a 54 kDa proenzyme that is processed into a 45 kDa and then a 22 kDa active form(15723202). MMP9 and MMP12 promote intimal thickening by independent cleavage of N-cadherin, which elevates vascular smooth muscle cell proliferation via beta-catenin signalling. Its overexpression in myeloid lineage cells plays a key role in modulating myelopoiesis, immune suppression, and lung tumorigenesis(PMID: 21378275).
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