产品
本公司产品仅供体外研究使用，不用于临床诊断
NR1H3 antibody
| 规格 | 价格 |
|---|---|
| 100μg | RMB ¥1900 |
| 50μg | RMB ¥1140 |
货期：
三个工作日+顺丰快递时长
- 产品名称
- NR1H3 antibody
- 货号
- FNab05836
- 规格
- 100μg
- 状态
- liquid
- 纯化方法
- Protein A+G purification
- 纯度
- ≥95% as determined by SDS-PAGE
- 克隆性
- monoclonal
- 亚型
- IgG2a
- Clone ID
- 7D2
- 存储
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
免疫原信息
- 免疫原
- nuclear receptor subfamily 1, group H, member 3
- 别称
- Oxysterols receptor LXR-alpha|Liver X receptor alpha|Nuclear receptor subfamily 1 group H member 3|NR1H3|LXRA antibody
- UniProt ID
- Q13133
- 分子量
- 48 kDa
验证实验
- 验证实验
- ELISA, WB, IF
- 建议稀释比例
- WB: 1:200-1:1000; IF: 1:10-1:100
验证图片
MCF7 cells were subjected to SDS PAGE followed by western blot with FNab05836(NR1H3 antibody) at dilution of 1:500
Immunofluorescent analysis of HepG2 cells using FNab05836( NR1H3 Antibody) at dilution of 1:25 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Mouse IgG(H+L)
- 背景介绍
- Nuclear receptor. Interaction with RXR shifts RXR from its role as a silent DNA-binding partner to an active ligand-binding subunit in mediating retinoid responses through target genes defined by LXRES. LXRES are DR4-type response elements characterized by direct repeats of two similar hexanuclotide half-sites spaced by four nucleotides. Plays an important role in the regulation of cholesterol homeostasis, regulating cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8. Interplays functionally with RORA for the regulation of genes involved in liver metabolism(By similarity). Exhibits a ligand-dependent transcriptional activation activity(PubMed:25661920).
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