产品
本公司产品仅供体外研究使用，不用于临床诊断
- 产品名称
- NRG1 antibody
- 货号
- FNab05856
- 规格
- 100μg
- 状态
- liquid
- 纯化方法
- Immunogen affinity purified
- 纯度
- ≥95% as determined by SDS-PAGE
- 克隆性
- polyclonal
- 亚型
- IgG
- 存储
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
免疫原信息
- 免疫原
- neuregulin 1
- 别称
- Pro-neuregulin-1 antibody, membrane-bound isoform (Pro-NRG1)|Neuregulin-1 Alternative names: Acetylcholine receptor-inducing activity (ARIA)|Breast cancer cell differentiation factor p45|Glial growth factor|Heregulin (HRG)|Neu differentiation factor|Sensory and motor neuron-derived factor|NRG1|GGF|HGL|HRGA|NDF|SMDF antibody
- UniProt ID
- Q02297
- 分子量
- 55 kDa and 72 kDa
验证实验
- 验证实验
- ELISA, WB, IHC, IF, IP
- 建议稀释比例
- WB: 1:500-1:1000; IHC: 1:50-1:200 IP:1:500-1:2000; IF: 1:50-1:500
验证图片
human liver tissue were subjected to SDS PAGE followed by western blot with FNab05856(NRG1 antibody) at dilution of 1:250
IP Result of anti-NRG1 (IP:FNab05856, 4ug; Detection:FNab05856 1:1000) with mouse liver tissue lysate 4000ug.
Immunohistochemistry of paraffin-embedded human breast cancer using FNab05856(NRG1 antibody) at dilution of 1:100
Immunofluorescent analysis of HepG2 cells using FNab05856 (NRG1 antibody) at dilution of 1:25 and Alexa Fluor 488-conjugated Goat Anti-Rabbit IgG(H+L)
- 背景介绍
- Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. The multiple isoforms perform diverse functions such as inducing growth and differentiation of epithelial, glial, neuronal, and skeletal muscle cells; inducing expression of acetylcholine receptor in synaptic vesicles during the formation of the neuromuscular junction; stimulating lobuloalveolar budding and milk production in the mammary gland and inducing differentiation of mammary tumor cells; stimulating Schwann cell proliferation; implication in the development of the myocardium such as trabeculation of the developing heart. Isoform 10 may play a role in motor and sensory neuron development. Binds to ERBB4(PubMed:10867024, PubMed:7902537). Binds to ERBB3(PubMed:20682778). Acts as a ligand for integrins and binds(via EGF domain) to integrins ITGAV:ITGB3 or ITGA6:ITGB4. Its binding to integrins and subsequent ternary complex formation with integrins and ERRB3 are essential for NRG1-ERBB signaling. Induces the phosphorylation and activation of MAPK3/ERK1, MAPK1/ERK2 and AKT1(PubMed:20682778). Ligand-dependent ERBB4 endocytosis is essential for the NRG1-mediated activation of these kinases in neurons(By similarity).
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