Y79 cells were subjected to SDS PAGE followed by western blot with FNab05886(NUAK2 antibody) at dilution of 1:400
Immunohistochemistry of paraffin-embedded human kidney using FNab05886(NUAK2 antibody) at dilution of 1:50
背景介绍
Stress-activated kinase involved in tolerance to glucose starvation. Induces cell-cell detachment by increasing F-actin conversion to G-actin. Expression is induced by CD95 or TNF-alpha, via NF-kappa-B. Protects cells from CD95-mediated apoptosis and is required for the increased motility and invasiveness of CD95-activated tumor cells. Able to phosphorylate 'Ser-464' of LATS1.