HEK-293 cells were subjected to SDS PAGE followed by western blot with FNab06017(OSBPL10 antibody) at dilution of 1:400
IP result of anti-OSBPL10(FNab06017 for IP and Detection).
Immunohistochemistry of paraffin-embedded human colon cancer using FNab06017(OSBPL10 antibody) at dilution of 1:50
背景介绍
Probable lipid transporter involved in lipid countertransport between the endoplasmic reticulum and the plasma membrane. Its ability to bind phosphatidylserine, suggests that it specifically exchanges phosphatidylserine with phosphatidylinositol 4-phosphate(PI4P), delivering phosphatidylserine to the plasma membrane in exchange for PI4P(PubMed:23934110)(Probable). Plays a role in negative regulation of lipid biosynthesis(PubMed:19554302). Negatively regulates APOB secretion from hepatocytes(PubMed:19554302, PubMed:22906437). Binds cholesterol and acidic phospholipids(PubMed:22906437). Also binds 25-hydroxycholesterol(PubMed:17428193). Binds phosphatidylserine(PubMed:23934110).