产品
本公司产品仅供体外研究使用，不用于临床诊断
PARD3 antibody
| 规格 | 价格 |
|---|---|
| 100μg | RMB ¥1750 |
| 50μg | RMB ¥1050 |
货期：
三个工作日+顺丰快递时长
- 产品名称
- PARD3 antibody
- 货号
- FNab06146
- 规格
- 100μg
- 状态
- liquid
- 纯化方法
- Immunogen affinity purified
- 纯度
- ≥95% as determined by SDS-PAGE
- 克隆性
- polyclonal
- 亚型
- IgG
- 存储
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
免疫原信息
- 免疫原
- Partitioning defective 3 homolog
- 别称
- Partitioning defective 3 homolog (PAR-3 antibody, PARD-3)|Atypical PKC isotype-specific-interacting protein (ASIP)|CTCL tumor antigen se2-5|PAR3-alpha|PARD3|PAR3|PAR3A antibody
- UniProt ID
- Q8TEW0
- 分子量
- 100 kDa, 150 kDa, and 180 kDa
验证实验
- 验证实验
- ELISA, WB, IHC, FC, IP
- 建议稀释比例
- WB: 1:500-1:1000; IP: 1:200-1:1000; IHC: 1:50-1:200; IF: 1:50-1:500
验证图片
MCF7 cells were subjected to SDS PAGE followed by western blot with FNab06146(PARD3 antibody) at dilution of 1:500
IP Result of anti-PARD3 (IP:FNab06146, 4ug; Detection:FNab06146 1:200) with MCF-7 cells lysate 2900ug.
Immunohistochemistry of paraffin-embedded human colon cancer using FNab06146(PARD3 antibody) at dilution of 1:50
Immunofluorescent analysis of fixed MCF-7 cells using FNab06146 (PARD3 antibody) at dilution of 1:50 and Alexa Fluor 488-conjugated Goat Anti-Rabbit IgG(H+L)
- 背景介绍
- Adapter protein involved in asymmetrical cell division and cell polarization processes. Seems to play a central role in the formation of epithelial tight junctions. Targets the phosphatase PTEN to cell junctions. Involved in Schwann cell peripheral myelination(By similarity). Association with PARD6B may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins. Required for establishment of neuronal polarity and normal axon formation in cultured hippocampal neurons.PARD3 has three splice isoforms at 100 kDa, 150 kDa, and 180 kDa. This polyclonal antibody raised against C-terminal 281 amino acids of human PARD3 recognizes these three isoforms.
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