human kidney tissue were subjected to SDS PAGE followed by western blot with FNab06158(PARP3 antibody) at dilution of 1:500
Immunohistochemistry of paraffin-embedded human pancreas cancer using FNab06158(PARP3 antibody) at dilution of 1:50
背景介绍
Involved in the base excision repair(BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. May link the DNA damage surveillance network to the mitotic fidelity checkpoint. Negatively influences the G1/S cell cycle progression without interfering with centrosome duplication. Binds DNA. May be involved in the regulation of PRC2 and PRC3 complex-dependent gene silencing.