HeLa cells were subjected to SDS PAGE followed by western blot with FNab06883( PSMD11 Antibody) at dilution of 1:1000
IP Result of anti-PSMD11 (IP:FNab06883, 3ug; Detection:FNab06883 1:500) with MCF-7 cells lysate 2000ug.
背景介绍
Component of the lid subcomplex of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. In the complex, PSMD11 is required for proteasome assembly. Plays a key role in increased proteasome activity in embryonic stem cells(ESCs): its high expression in ESCs promotes enhanced assembly of the 26S proteasome, followed by higher proteasome activity.