产品
本公司产品仅供体外研究使用，不用于临床诊断
PTEN antibody
| 规格 | 价格 |
|---|---|
| 100μg | RMB ¥1900 |
| 50μg | RMB ¥1140 |
货期：
三个工作日+顺丰快递时长
- 产品名称
- PTEN antibody
- 货号
- FNab06912
- 规格
- 100μg
- 状态
- liquid
- 纯化方法
- Protein A+G purification
- 纯度
- ≥95% as determined by SDS-PAGE
- 克隆性
- monoclonal
- 亚型
- IgG1
- Clone ID
- 9E6
- 存储
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
免疫原信息
- 免疫原
- phosphatase and tensin homolog
- 别称
- Phosphatidylinositol 3 antibody, 4 antibody, 5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN|Inositol polyphosphate 3-phosphatase|Mutated in multiple advanced cancers 1|Phosphatase and tensin homolog|PTEN|MMAC1|TEP1 antibody
- UniProt ID
- P60484
- 分子量
- 47 kDa
验证实验
- 验证实验
- ELISA, IHC, WB, IF
- 建议稀释比例
- WB: 1:1000-1:4000; IHC: 1:200-1:1000; IF: 1:20-1:200
验证图片
DU 145 cells were subjected to SDS PAGE followed by western blot with FNab06912(PTEN Antibody) at dilution of 1:2000
Immunohistochemistry of paraffin-embedded human lung cancer tissue slide using FNab06912(PTEN Antibody) at dilution of 1:500
Immunofluorescent analysis of HepG2 cells using FNab06912 (PTEN antibody) at dilution of 1:50 and Alexa Fluor 488-conjugated Goat Anti-Mouse IgG(H+L)
- 背景介绍
- This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded by this gene is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway. The use of a non-canonical (CUG) upstream initiation site produces a longer isoform that initiates translation with a leucine, and is thought to be preferentially associated with the mitochondrial inner membrane. This longer isoform may help regulate energy metabolism in the mitochondria. A pseudogene of this gene is found on chromosome 9. Alternative splicing and the use of multiple translation start codons results in multiple transcript variants encoding different isoforms.
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