rat brain tissue were subjected to SDS PAGE followed by western blot with FNab06918( PTGES3 Antibody) at dilution of 1:1000
IP Result of anti-PTGES3 (IP:FNab06918, 3ug; Detection:FNab06918 1:300) with mouse heart tissue lysate 4000ug.
背景介绍
Cytosolic prostaglandin synthase that catalyzes the oxidoreduction of prostaglandin endoperoxide H2(PGH2) to prostaglandin E2(PGE2)(PubMed:10922363). Molecular chaperone that localizes to genomic response elements in a hormone-dependent manner and disrupts receptor-mediated transcriptional activation, by promoting disassembly of transcriptional regulatory complexes(PubMed:11274138, PubMed:12077419). Facilitates HIF alpha proteins hydroxylation via interaction with EGLN1/PHD2, leading to recruit EGLN1/PHD2 to the HSP90 pathway(PubMed:24711448).