产品
本公司产品仅供体外研究使用，不用于临床诊断
RAB5A antibody
| 规格 | 价格 |
|---|---|
| 100μg | RMB ¥1750 |
| 50μg | RMB ¥1050 |
货期：
三个工作日+顺丰快递时长
- 产品名称
- RAB5A antibody
- 货号
- FNab07038
- 规格
- 100μg
- 状态
- liquid
- 纯化方法
- Immunogen affinity purified
- 纯度
- ≥95% as determined by SDS-PAGE
- 克隆性
- polyclonal
- 亚型
- IgG
- 存储
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
免疫原信息
- 免疫原
- RAB5A, member RAS oncogene family
- 别称
- Ras-related protein Rab-5A|RAB5A|RAB5 antibody
- UniProt ID
- P20339
- 分子量
- 24 kDa
验证实验
- 验证实验
- ELISA, IHC, WB, IP,IF
- 建议稀释比例
- WB: 1:200-1:2000; IP:1:200-1:2000; IHC: 1:50-1:500; IF: 1:50-1:500
验证图片
mouse brain tissue were subjected to SDS PAGE followed by western blot with FNab07038(RAB5A antibody) at dilution of 1:500
IP Result of anti-RAB5A (IP:FNab07038, 4ug; Detection:FNab07038 1:500) with mouse brain tissue lysate 4000ug.
Immunohistochemistry of paraffin-embedded human gliomas tissue slide using FNab07038(RAB5A Antibody) at dilution of 1:200 heat mediated antigen retrieved with Tris-EDTA buffer(pH9).
Immunofluorescent analysis of ( -20℃ Ethanol ) fixed HeLa cells using FNab07038( RAB5A Antibody) at dilution of 1:50 and Alexa Fluor 488-conjugated Goat Anti-Rabbit IgG(H+L)
- 背景介绍
- The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB5A is required for the fusion of plasma membranes and early endosomes(PubMed:10818110, PubMed:14617813, PubMed:16410077, PubMed:15378032). Contributes to the regulation of filopodia extension(PubMed:14978216). Required for the exosomal release of SDCBP, CD63, PDCD6IP and syndecan(PubMed:22660413). Regulates maturation of apoptotic cell-containing phagosomes, probably downstream of DYN2 and PIK3C3(By similarity).
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