mouse lung tissue were subjected to SDS PAGE followed by western blot with FNab07134(RASIP1 Antibody) at dilution of 1:300
Immunohistochemistry of paraffin-embedded human lung tissue slide using FNab07134(RASIP1 Antibody) at dilution of 1:50
背景介绍
Required for the proper formation of vascular structures that develop via both vasculogenesis and angiogenesis. Acts as a critical and vascular-specific regulator of GTPase signaling, cell architecture, and adhesion, which is essential for endothelial cell morphogenesis and blood vessel tubulogenesis. Regulates the activity of Rho GTPases in part by recruiting ARHGAP29 and suppressing RhoA signaling and dampening ROCK and MYH9 activities in endothelial cells(By similarity). May act as effector for Golgi-bound HRAS and other Ras-like proteins. May promote HRAS-mediated transformation. Negative regulator of amino acid starvation-induced autophagy.