mouse lung tissue were subjected to SDS PAGE followed by western blot with FNab07268(RGS17 antibody) at dilution of 1:1000
Immunohistochemistry of paraffin-embedded human testis slide using FNab07268(RGS17 Antibody) at dilution of 1:50
背景介绍
Regulates G protein-coupled receptor signaling cascades, including signaling via muscarinic acetylcholine receptor CHRM2 and dopamine receptor DRD2. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form(PubMed:15096504). Binds selectively to GNAZ and GNAI2 subunits, accelerates their GTPase activity and regulates their signaling activities. Negatively regulates mu-opioid receptor-mediated activation of the G-proteins(By similarity).