SH-SY5Y cells were subjected to SDS PAGE followed by western blot with FNab07273(RGS7 antibody) at dilution of 1:500
Immunohistochemistry of paraffin-embedded human gliomas using FNab07273(RGS7 antibody) at dilution of 1:50
背景介绍
Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form(PubMed:10521509, PubMed:10862767). The RGS7/GNB5 dimer enhances GNAO1 GTPase activity(PubMed:10521509). May play a role in synaptic vesicle exocytosis(PubMed:12659861). Modulates the activity of potassium channels that are activated by GNAO1 in response to muscarinic acetylcholine receptor M2/CHRM2 signaling(PubMed:15897264).