human brain tissue were subjected to SDS PAGE followed by western blot with FNab07295(RIC8A antibody) at dilution of 1:200
Immunohistochemistry of paraffin-embedded human pancreas cancer using FNab07295(RIC8A antibody) at dilution of 1:50
背景介绍
Guanine nucleotide exchange factor(GEF), which can activate some, but not all, G-alpha proteins. Able to activate GNAI1, GNAO1 and GNAQ, but not GNAS by exchanging bound GDP for free GTP. Involved in regulation of microtubule pulling forces during mitotic movement of chromosomes by stimulating G(i)-alpha protein, possibly leading to release G(i)-alpha-GTP and NuMA proteins from the NuMA-GPSM2-G(i)-alpha-GDP complex(By similarity). Also acts as an activator for G(q)-alpha(GNAQ) protein by enhancing the G(q)-coupled receptor-mediated ERK activation.