HepG2 cells were subjected to SDS PAGE followed by western blot with FNab07712(SENP1 Antibody) at dilution of 1:1000
Immunohistochemistry of paraffin-embedded human ovary tissue slide using FNab07712(SENP1 Antibody) at dilution of 1:50
背景介绍
Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO1, SUMO2 and SUMO3 to their mature forms and deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins. Deconjugates SUMO1 from HIPK2. Deconjugates SUMO1 from HDAC1 and BHLHE40/DEC1, which decreases its transcriptional repression activity. Deconjugates SUMO1 from CLOCK, which decreases its transcriptional activation activity. Deconjugates SUMO2 from MTA1. Desumoylates CCAR2 which decreases its interaction with SIRT1(PubMed:25406032).