产品
本公司产品仅供体外研究使用，不用于临床诊断
SHARPIN antibody
| 规格 | 价格 |
|---|---|
| 100μg | RMB ¥1900 |
| 50μg | RMB ¥1140 |
货期：
三个工作日+顺丰快递时长
- 产品名称
- SHARPIN antibody
- 货号
- FNab07838
- 规格
- 100μg
- 状态
- liquid
- 纯化方法
- Immunogen affinity purified
- 纯度
- ≥95% as determined by SDS-PAGE
- 克隆性
- polyclonal
- 亚型
- IgG
- 存储
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
免疫原信息
- 免疫原
- SHANK-associated RH domain interactor
- 别称
- Sharpin|Shank-associated RH domain-interacting protein|Shank-interacting protein-like 1 (hSIPL1)|SHARPIN|SIPL1 antibody
- UniProt ID
- Q9H0F6
- 分子量
- 40 kDa
验证实验
- 验证实验
- ELISA, WB, IP, IHC
- 建议稀释比例
- WB: 1:500-1:2000; IP: 1:200-1:1000; IHC: 1:20-1:200
验证图片
Raji cells were subjected to SDS PAGE followed by western blot with FNab07838(SHARPIN antibody) at dilution of 1:500
IP Result of anti-SHARPIN (IP:FNab07838, 3ug; Detection:FNab07838 1:1500) with Raji cells lysate 2520ug.
Immunohistochemistry of paraffin-embedded human small intestine tissue slide using FNab07838(SHARPIN Antibody) at dilution of 1:200 heat mediated antigen retrieved with Tris-EDTA buffer(pH9).
- 背景介绍
- Component of the LUBAC complex which conjugates linear polyubiquitin chains in a head-to-tail manner to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation. LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways. Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation. LUBAC is proposed to be recruited to the TNF-R1 signaling complex(TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex. Together with FAM105B/otulin, the LUBAC complex regulates the canonical Wnt signaling during angiogenesis.
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