SLAM family member 7|CD2 subset 1|CD2-like receptor-activating cytotoxic cells (CRACC)|Membrane protein FOAP-12|Novel Ly9|Protein 19A|SLAMF7|CS1 antibody
货号:
FNab07903
反应性:
Human
宿主:
Rabbit
验证实验:
ELISA, WB
克隆性:
polyclonal
亚型:
IgG
规格
价格
100μg
RMB ¥2100
50μg
RMB ¥1260
货期:
三个工作日+顺丰快递时长
产品介绍
实验结果
实验条件
常见问题
产品名称
SLAMF7 antibody
货号
FNab07903
规格
100μg
状态
liquid
纯化方法
Immunogen affinity purified
纯度
≥95% as determined by SDS-PAGE
克隆性
polyclonal
亚型
IgG
存储
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
免疫原信息
免疫原
SLAM family member 7
别称
SLAM family member 7|CD2 subset 1|CD2-like receptor-activating cytotoxic cells (CRACC)|Membrane protein FOAP-12|Novel Ly9|Protein 19A|SLAMF7|CS1 antibody
Jurkat cells were subjected to SDS PAGE followed by western blot with FNab07903( SLAMF7 Antibody) at dilution of 1:600
背景介绍
Self-ligand receptor of the signaling lymphocytic activation molecule(SLAM) family. SLAM receptors triggered by homo-or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. Isoform 1 mediates NK cell activation through a SH2D1A-independent extracellular signal-regulated ERK-mediated pathway(PubMed:11698418). Positively regulates NK cell functions by a mechanism dependent on phosphorylated SH2D1B. Downstream signaling implicates PLCG1, PLCG2 and PI3K(PubMed:16339536). In addition to heterotypic NK cells-target cells interactions also homotypic interactions between NK cells may contribute to activation. However, in the absence of SH2D1B, inhibits NK cell function. Acts also inhibitory in T-cells(By similarity). May play a role in lymphocyte adhesion(PubMed:11802771). In LPS-activated monocytes negatively regulates production of proinflammatory cytokines(PubMed:23695528). Isoform 3 does not mediate any NK cell activation.