mouse testis tissue were subjected to SDS PAGE followed by western blot with FNab08335(STK36 antibody) at dilution of 1:300
IP Result of anti-STK36 (IP:FNab08335, 4ug; Detection:FNab08335 1:500) with mouse testis tissue lysate 4000ug.
Immunohistochemistry of paraffin-embedded human prostate using FNab08335(STK36 antibody) at dilution of 1:50
背景介绍
Serine/threonine protein kinase which plays an important role in the sonic hedgehog(Shh) pathway by regulating the activity of GLI transcription factors(PubMed:10806483). Controls the activity of the transcriptional regulators GLI1, GLI2 and GLI3 by opposing the effect of SUFU and promoting their nuclear localization(PubMed:10806483). GLI2 requires an additional function of STK36 to become transcriptionally active, but the enzyme does not need to possess an active kinase catalytic site for this to occur(PubMed:10806483). Required for postnatal development, possibly by regulating the homeostasis of cerebral spinal fluid or ciliary function(By similarity). Essential for construction of the central pair apparatus of motile cilia.