产品
本公司产品仅供体外研究使用，不用于临床诊断
TAP1 antibody
| 规格 | 价格 |
|---|---|
| 100μg | RMB ¥1900 |
| 50μg | RMB ¥1140 |
| 20μg | RMB ¥570 |
货期：
三个工作日+顺丰快递时长
- 产品名称
- TAP1 antibody
- 货号
- FNab08499
- 规格
- 100μg
- 状态
- liquid
- 纯化方法
- Immunogen affinity purified
- 纯度
- ≥95% as determined by SDS-PAGE
- 克隆性
- polyclonal
- 亚型
- IgG
- 存储
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
免疫原信息
- 免疫原
- transporter 1, ATP-binding cassette, sub-family B(MDR/TAP)
- 别称
- Antigen peptide transporter 1 (APT1)|ATP-binding cassette sub-family B member 2|Peptide supply factor 1|Peptide transporter PSF1 (PSF-1)|Peptide transporter TAP1|Peptide transporter involved in antigen processing 1|Really interesting new gene 4 protein (RING4)|TAP1|ABCB2|PSF1|RING4|Y3 antibody
- UniProt ID
- Q03518
- 分子量
- 70-81 kDa
验证实验
- 验证实验
- ELISA, IF, WB, IHC, IP
- 建议稀释比例
- WB: 1:500-1:2000; IP: 1:200-1:2000; IHC: 1:20-1:200; IF: 1:20-1:200
验证图片
HepG2 cells were subjected to SDS PAGE followed by western blot with FNab08499(TAP1 Antibody) at dilution of 1:1000
IP Result of anti-TAP1 (IP:FNab08499, 4ug; Detection:FNab08499 1:500) with HepG2 cells lysate 2400ug.
Immunohistochemistry of paraffin-embedded human pancreas cancer tissue slide using FNab08499(TAP1 Antibody) at dilution of 1:50
- 背景介绍
- Involved in the transport of antigens from the cytoplasm to the endoplasmic reticulum for association with MHC class I molecules. Also acts as a molecular scaffold for the final stage of MHC class I folding, namely the binding of peptide. Nascent MHC class I molecules associate with TAP via tapasin. Inhibited by the covalent attachment of herpes simplex virus ICP47 protein, which blocks the peptide-binding site of TAP. Inhibited by human cytomegalovirus US6 glycoprotein, which binds to the lumenal side of the TAP complex and inhibits peptide translocation by specifically blocking ATP-binding to TAP1 and prevents the conformational rearrangement of TAP induced by peptide binding. Inhibited by human adenovirus E3-19K glycoprotein, which binds the TAP complex and acts as a tapasin inhibitor, preventing MHC class I/TAP association. Expression of TAP1 is down-regulated by human Epstein-Barr virus vIL-10 protein, thereby affecting the transport of peptides into the endoplasmic reticulum and subsequent peptide loading by MHC class I molecules.
抗体定制服务
抗体定制服务
