Jurkat cells were subjected to SDS PAGE followed by western blot with FNab08510(TBC1D17 antibody) at dilution of 1:1000
Immunohistochemistry of paraffin-embedded human breast cancer tissue slide using FNab08510(TBC1D17 Antibody) at dilution of 1:50
背景介绍
Probable GTPase-activating protein for Rab8; its transient association with Rab8 is mediated by OPTN. Inhibits Rab8-mediated endocytic trafficking, such as of transferrin receptor(TfR) and reduces Rab8 recruitnment to tubules emanating from the endocytic recycling compartment(ERC). Involved in regulation of autophagy. Mediates inhibition of autophagy caused by the OPTN variant GLC1E LYS-50; the function requires its catalytic activity, however, the involved Rab is not known.