TIR domain-containing adapter molecule 2 (TICAM-2)|Putative NF-kappa-B-activating protein 502|TRIF-related adapter molecule|Toll-like receptor adaptor protein 3|Toll/interleukin-1 receptor domain-containing protein (MyD88-4)|TICAM2|TIRAP3|TIRP|TRAM antibody
货号:
FNab08687
反应性:
Human
宿主:
Rabbit
验证实验:
ELISA, WB, IHC
克隆性:
polyclonal
亚型:
IgG
规格
价格
100μg
RMB ¥2100
50μg
RMB ¥1260
货期:
三个工作日+顺丰快递时长
产品介绍
实验结果
实验条件
常见问题
产品名称
TICAM2 antibody
货号
FNab08687
规格
100μg
状态
liquid
纯化方法
Immunogen affinity purified
纯度
≥95% as determined by SDS-PAGE
克隆性
polyclonal
亚型
IgG
存储
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
免疫原信息
免疫原
toll-like receptor adaptor molecule 2
别称
TIR domain-containing adapter molecule 2 (TICAM-2)|Putative NF-kappa-B-activating protein 502|TRIF-related adapter molecule|Toll-like receptor adaptor protein 3|Toll/interleukin-1 receptor domain-containing protein (MyD88-4)|TICAM2|TIRAP3|TIRP|TRAM antibody
PC-3 cells were subjected to SDS PAGE followed by western blot with FNab08687(TICAM2 antibody) at dilution of 1:500
Immunohistochemistry of paraffin-embedded human testis tissue slide using FNab08687(TICAM2 Antibody) at dilution of 1:50
背景介绍
Functions as sorting adapter in LPS-TLR4 signaling to regulate the MYD88-independent pathway during the innate immune response to LPS. Physically bridges TLR4 and TICAM1 and functionally transmits LPS-TRL4 signal to TICAM1; signaling is proposed to occur in early endosomes after endocytosis of TLR4. May also be involved in IL1-triggered NF-kappa-B activation, functioning upstream of IRAK1, IRAK2, TRAF6, and IKBKB; however, reports are controversial. Involved in IL-18 signaling and is proposed to function as a sorting adaptor for MYD88 in IL-18 signaling during adaptive immune response.Isoform 2: Proposed to inhibit LPS-TLR4 signaling at the late endosome by interaction with isoform 1 thereby disrupting the association of isoform 1 with TICAM1. May be involved in TLR4 degradation in late endosomes.