Immunohistochemistry of paraffin-embedded human tonsillitis slide using FNab08726(TLR3 antibody) at dilution of 1:50
背景介绍
Key component of innate and adaptive immunity. TLRs(Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR3 is a nucleotide-sensing TLR which is activated by double-stranded RNA, a sign of viral infection. Acts via the adapter TRIF/TICAM1, leading to NF-kappa-B activation, IRF3 nuclear translocation, cytokine secretion and the inflammatory response.