产品
本公司产品仅供体外研究使用，不用于临床诊断
TRPV6 antibody
| 规格 | 价格 |
|---|---|
| 100μg | RMB ¥1900 |
| 50μg | RMB ¥1140 |
货期：
三个工作日+顺丰快递时长
- 产品名称
- TRPV6 antibody
- 货号
- FNab09030
- 规格
- 100μg
- 状态
- liquid
- 纯化方法
- Immunogen affinity purified
- 纯度
- ≥95% as determined by SDS-PAGE
- 克隆性
- polyclonal
- 亚型
- IgG
- 存储
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
免疫原信息
- 免疫原
- transient receptor potential cation channel, subfamily V, member 6
- 别称
- Transient receptor potential cation channel subfamily V member 6 (TrpV6)|CaT-like (CaT-L)|Calcium transport protein 1 (CaT1)|Epithelial calcium channel 2 (ECaC2)|TRPV6|ECAC2 antibody
- UniProt ID
- Q9H1D0
- 分子量
- 82 kDa, 70 kDa
验证实验
- 验证实验
- ELISA, IF, WB, IP
- 建议稀释比例
- WB: 1:500-1:5000; IP: 1:200-1:1000; IF: 1:10-1:100
验证图片
human placenta tissue were subjected to SDS PAGE followed by western blot with FNab09030(TRPV6 Antibody) at dilution of 1:1000
IP Result of anti-TRPV6 (IP:FNab09030, 4ug; Detection:FNab09030 1:300) with mouse kidney tissue lysate 4000ug.
- 背景介绍
- Calcium selective cation channel that mediates Ca(2+) uptake in various tissues, including the intestine(PubMed:11097838, PubMed:11278579, PubMed:11248124 PubMed:15184369, PubMed:23612980). Important for normal Ca(2+) ion homeostasis in the body, including bone and skin(By similarity). The channel is activated by low internal calcium level, probably including intracellular calcium store depletion, and the current exhibits an inward rectification(PubMed:15184369). Inactivation includes both a rapid Ca(2+)-dependent and a slower Ca(2+)-calmodulin-dependent mechanism; the latter may be regulated by phosphorylation. In vitro, is slowly inhibited by Mg(2+) in a voltage-independent manner. Heteromeric assembly with TRPV5 seems to modify channel properties. TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating.
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