Jurkat cells were subjected to SDS PAGE followed by western blot with FNab09048(TSN Antibody) at dilution of 1:600
IP Result of anti-TSN (IP:FNab09048, 3ug; Detection:FNab09048 1:300) with MCF-7 cells lysate 1600ug.
Immunohistochemistry of paraffin-embedded human testis tissue slide using FNab09048(TSN Antibody) at dilution of 1:50
背景介绍
DNA-binding protein that specifically recognizes consensus sequences at the breakpoint junctions in chromosomal translocations, mostly involving immunoglobulin(Ig)/T-cell receptor gene segments. Seems to recognize single-stranded DNA ends generated by staggered breaks occurring at recombination hot spots.Exhibits both single-stranded and double-stranded endoribonuclease activity. May act as an activator of RNA-induced silencing complex(RISC) by facilitating endonucleolytic cleavage of the siRNA passenger strand.