SH-SY5Y cells were subjected to SDS PAGE followed by western blot with FNab09109(TULP3 antibody) at dilution of 1:800
IP Result of anti-TULP3 (IP:FNab09109, 4ug; Detection:FNab09109 1:800) with SH-SY5Y cells lysate 1600ug.
Immunohistochemistry of paraffin-embedded human ovary tumor using FNab09109(TULP3 antibody) at dilution of 1:100
背景介绍
Negative regulator of the Shh signaling transduction pathway: recruited to primary cilia via association with the IFT complex A(IFT-A) and is required for recruitment of G protein-coupled receptor GPR161 to cilia, a promoter of PKA-dependent basal repression machinery in Shh signaling. Binds to phosphorylated inositide(phosphoinositide) lipids. Both IFT-A-and phosphoinositide-binding properties are required to regulate ciliary G protein-coupled receptor trafficking. Not involved in ciliogenesis.