SH-SY5Y cells were subjected to SDS PAGE followed by western blot with FNab09120(TWSG1 Antibody) at dilution of 1:300
Immunohistochemistry of paraffin-embedded mouse brain tissue slide using FNab09120(TWSG1 Antibody) at dilution of 1:50
背景介绍
May be involved in dorsoventral axis formation. Seems to antagonize BMP signaling by forming ternary complexes with CHRD and BMPs, thereby preventing BMPs from binding to their receptors. In addition to the anti-BMP function, also has pro-BMP activity, partly mediated by cleavage and degradation of CHRD, which releases BMPs from ternary complexes. May be an important modulator of BMP-regulated cartilage development and chondrocyte differentiation. May play a role in thymocyte development(By similarity).