产品
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TXNIP antibody
| 规格 | 价格 |
|---|---|
| 100μg | RMB ¥1900 |
| 50μg | RMB ¥1140 |
货期：
三个工作日+顺丰快递时长
- 产品名称
- TXNIP antibody
- 货号
- FNab09129
- 规格
- 100μg
- 状态
- liquid
- 纯化方法
- Immunogen affinity purified
- 纯度
- ≥95% as determined by SDS-PAGE
- 克隆性
- polyclonal
- 亚型
- IgG
- 存储
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
免疫原信息
- 免疫原
- thioredoxin interacting protein
- 别称
- Thioredoxin-interacting protein|Thioredoxin-binding protein 2|Vitamin D3 up-regulated protein 1|TXNIP|VDUP1 antibody
- UniProt ID
- Q9H3M7
- 分子量
- 50 kDa
验证实验
- 验证实验
- ELISA, IHC, WB, IF
- 建议稀释比例
- WB: 1:200-1:2000; IP: 1:200-1:2000; IHC: 1:50-1:500; IF: 1:10-1:100
验证图片
K-562 cells were subjected to SDS PAGE followed by western blot with FNab09129(TXNIP Antibody) at dilution of 1:600
IP Result of anti-TXNIP (IP: FNab09129, 4ug; Detection: FNab09129 1:500) with K-562 cells lysate 4000ug.
Immunohistochemistry of paraffin-embedded human kidney tissue slide using FNab09129(TXNIP Antibody) at dilution of 1:200
Immunofluorescent analysis of HeLa cells using FNab09129 (TXNIP antibody) at dilution of 1:25 and Alexa Fluor 488-conjugated Goat Anti-Rabbit IgG(H+L)
- 背景介绍
- May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. Functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over-expression will induce G0/G1 cell cycle arrest. Required for the maturation of natural killer cells. Acts as a suppressor of tumor cell growth. Inhibits the proteasomal degradation of DDIT4, and thereby contributes to the inhibition of the mammalian target of rapamycin complex 1(mTORC1).
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