产品
本公司产品仅供体外研究使用，不用于临床诊断
USP2 antibody
¥1900
规格：
货期：
三个工作日+顺丰&京东快递时长
- 产品名称
- USP2 antibody
- 货号
- FNab09315
- 规格
- 100μg
- 状态
- liquid
- 纯化方法
- Immunogen affinity purified
- 纯度
- ≥95% as determined by SDS-PAGE
- 克隆性
- polyclonal
- 亚型
- IgG
- 存储
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
免疫原信息
- 免疫原
- ubiquitin specific peptidase 2
- 别称
- Deubiquitinating enzyme 2 antibody, ubiquitin specific peptidase 2 antibody, Ubiquitin thiolesterase 2 antibody, UBP41 antibody, USP2 antibody, USP9 antibody
- UniProt ID
- O75604
- 分子量
- 68 kDa
验证实验
- 验证实验
- ELISA, WB, IHC, IF
- 建议稀释比例
- WB: 1:200-1:2000; IHC: 1:20-1:200；IF：1:10-1:100
验证图片
MCF7 cells were subjected to SDS PAGE followed by western blot with FNab09315(USP2 Antibody) at dilution of 1:1000
Immunohistochemical of paraffin-embedded human skeletal muscle using FNab09315(USP2 antibody) at dilution of 1:50
- 背景介绍
- Hydrolase that deubiquitinates polyubiquitinated target proteins such as MDM2, MDM4 and CCND1. Isoform 1 and isoform 4 possess both ubiquitin-specific peptidase and isopeptidase activities. Deubiquitinates MDM2 without reversing MDM2-mediated p53/TP53 ubiquitination and thus indirectly promotes p53/TP53 degradation and limits p53 activity. Has no deubiquitinase activity against p53/TP53. Prevents MDM2-mediated degradation of MDM4. Plays a role in the G1/S cell-cycle progression in normal and cancer cells. Plays a role in the regulation of myogenic differentiation of embryonic muscle cells. Regulates the circadian clock by modulating its intrinsic circadian rhythm and its capacity to respond to external cues. Associates with clock proteins and deubiquitinates core clock component PER1 but does not affect its overall stability. Regulates the nucleocytoplasmic shuttling and nuclear retention of PER1 and its repressive role on the clock transcription factors CLOCK and ARNTL/BMAL1(By similarity).
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