HepG2 cells were subjected to SDS PAGE followed by western blot with FNab09319(USP22 antibody) at dilution of 1:300
背景介绍
Histone deubiquitinating component of the transcription regulatory histone acetylation(HAT) complex SAGA. Catalyzes the deubiquitination of both histones H2A and H2B, thereby acting as a coactivator. Recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation and cell cycle progression.