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VPS4B antibody
| 规格 | 价格 |
|---|---|
| 100μg | RMB ¥1900 |
| 50μg | RMB ¥1140 |
货期：
三个工作日+顺丰快递时长
- 产品名称
- VPS4B antibody
- 货号
- FNab09446
- 规格
- 100μg
- 状态
- liquid
- 纯化方法
- Immunogen affinity purified
- 纯度
- ≥95% as determined by SDS-PAGE
- 克隆性
- polyclonal
- 亚型
- IgG
- 存储
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
免疫原信息
- 免疫原
- vacuolar protein sorting 4 homolog B
- 别称
- Vacuolar protein sorting-associated protein 4B|Cell migration-inducing gene 1 protein|Suppressor of K(+) transport growth defect 1 (Protein SKD1)|VPS4B|SKD1|VPS42 antibody
- UniProt ID
- O75351
- 分子量
- 50 kDa
验证实验
- 验证实验
- ELISA, WB, IF, IP
- 建议稀释比例
- WB: 1:500-1:5000;IP: 1:500-1:5000;IF: 1:10-1:100
验证图片
Y79 cells were subjected to SDS PAGE followed by western blot with FNab09446(VPS4B antibody) at dilution of 1:500
IP Result of anti-VPS4B (IP:FNab09446, 4ug; Detection:FNab09446 1:1000) with HeLa cells lysate 880ug.
- 背景介绍
- Involved in late steps of the endosomal multivesicular bodies(MVB) pathway. Recognizes membrane-associated ESCRT-III assemblies and catalyzes their disassembly, possibly in combination with membrane fission. Redistributes the ESCRT-III components to the cytoplasm for further rounds of MVB sorting. MVBs contain intraluminal vesicles(ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. In conjunction with the ESCRT machinery also appears to function in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and enveloped virus budding(HIV-1 and other lentiviruses). VPS4A/B are required for the exosomal release of SDCBP, CD63 and syndecan(PubMed:22660413).
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