HepG2 cells were subjected to SDS PAGE followed by western blot with FNab09593(ZBTB38 antibody) at dilution of 1:1000
Immunohistochemistry of paraffin-embedded human testis using FNab09593(ZBTB38 antibody) at dilution of 1:50
背景介绍
Transcriptional regulator with bimodal DNA-binding specificity. Binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' but can also bind to E-box elements(5'-CACGTG-3'). Can also bind specifically to a single methyl-CpG pair. Represses transcription in a methyl-CpG-dependent manner(PubMed:16354688). Plays an important role in regulating DNA replication and common fragile sites(CFS) stability in a RBBP6-and MCM10-dependent manner; represses expression of MCM10 which plays an important role in DNA-replication(PubMed:24726359). Acts as a transcriptional activator. May be involved in the differentiation and/or survival of late postmitotic neurons(By similarity).