Immunohistochemistry of paraffin-embedded human lung cancer tissue slide using FNab09791(MIP-3α Antibody) at dilution of 1:200
背景介绍
CCL20, also known as macrophage in?ltrating factor protein 3α, is a C-C chemokine that speci?cally binds to the receptor CCR6. CCL20 is produced in various tissues and by a wide range of immune cells, including neutrophils, natural killer cells, T-helper type 17(Th17) cells, B cells, and various antigen-presenting cells, such as dendritic cells(DCs), Langerhans cells, and macrophages. Increased expression of CCL20 is likely involved in the increased recruitment of dendritic cells observed in fibroinflammatory diseases such as chronic obstructive pulmonary disease(COPD). CCL20 expression is increased by the proinflammatory cytokine IL-1 beta.