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CD44 antibody

分类: 研究方向:
别称:LHR antibody, MDU2 antibody, MDU3 antibody, MIC4 antibody
货号:FNab01483反应性:Human
宿主:Mouse验证实验:ELISA, WB, IHC, IF, FC
克隆性:monoclonal亚型:IgG2a
¥1750
规格:
货期: 三个工作日+顺丰快递时长
  • 产品介绍
产品名称
CD44 antibody
货号
FNab01483
规格
100μg
状态
liquid
纯化方法
Protein A+G purification
纯度
≥95% as determined by SDS-PAGE
克隆性
monoclonal
亚型
IgG2a
Clone ID
7D6
存储
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
免疫原信息
免疫原
CD44 molecule(Indian blood group)
别称
LHR antibody, MDU2 antibody, MDU3 antibody, MIC4 antibody
UniProt ID
P16070
分子量
80-95 kDa
验证实验
验证实验
ELISA, WB, IHC, IF, FC
建议稀释比例
WB: 1:500-1:5000; IHC: 1:50-1:200; IF: 1:10-1:100
验证图片
HeLa cells were subjected to SDS PAGE followed by western blot with FNab01483(CD44 antibody) at dilution of 1:1000
Immunohistochemistry of paraffin-embedded human lung cancer slide using FNab01483(CD44 Antibody) at dilution of 1:50
背景介绍
Receptor for hyaluronic acid(HA). Mediates cell-cell and cell-matrix interactions through its affinity for HA, and possibly also through its affinity for other ligands such as osteopontin, collagens, and matrix metalloproteinases(MMPs). Adhesion with HA plays an important role in cell migration, tumor growth and progression. In cancer cells, may play an important role in invadopodia formation. Also involved in lymphocyte activation, recirculation and homing, and in hematopoiesis. Altered expression or dysfunction causes numerous pathogenic phenotypes. Great protein heterogeneity due to numerous alternative splicing and post-translational modification events. Receptor for LGALS9; the interaction enhances binding of SMAD3 to the FOXP3 promoter, leading to up-regulation of FOXP3 expression and increased induced regulatory T(iTreg) cell stability and suppressive function(By similarity).