产品
本公司产品仅供体外研究使用，不用于临床诊断
TRAF2 antibody
¥1900
规格：
货期：
三个工作日+顺丰&京东快递时长
- 产品名称
- TRAF2 antibody
- 货号
- FNab10115
- 规格
- 100μg
- 状态
- liquid
- 纯化方法
- Immunogen affinity purified
- 纯度
- ≥95% as determined by SDS-PAGE
- 克隆性
- polyclonal
- 亚型
- IgG
- 存储
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
免疫原信息
- 免疫原
- TNF receptor-associated factor 2
- 别称
- TRAF2 antibody, TRAP antibody, TRAP3 antibody
- UniProt ID
- Q12933
- 分子量
- 54 kDa
验证实验
- 验证实验
- ELISA, WB, IF, IHC
- 建议稀释比例
- WB: 1:500-1:2000; IHC: 1:50-1:500; IF: 1:50-1:500
验证图片
HeLa cells were subjected to SDS PAGE followed by western blot with FNab10115 (TRAF2 antibody) at dilution of 1:1000
Immunohistochemical analysis of paraffin-embedded human liver cancer tissue slide using FNab10115( TRAF2 Antibody) at dilution of 1:200
- 背景介绍
- The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from members of the TNF receptor superfamily. This protein directly interacts with TNF receptors, and forms a heterodimeric complex with TRAF1. This protein is required for TNF-alpha-mediated activation of MAPK8/JNK and NF-kappaB. The protein complex formed by this protein and TRAF1 interacts with the inhibitor-of-apoptosis proteins (IAPs), and functions as a mediator of the anti-apoptotic signals from TNF receptors. The interaction of this protein with TRADD, a TNF receptor associated apoptotic signal transducer, ensures the recruitment of IAPs for the direct inhibition of caspase activation. BIRC2/c-IAP1, an apoptosis inhibitor possessing ubiquitin ligase activity, can unbiquitinate and induce the degradation of this protein, and thus potentiate TNF-induced apoptosis. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of only one transcript has been determined.
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