TRAF2 antibody

别称:TNF receptor-associated factor 2|E3 ubiquitin-protein ligase TRAF2|RING-type E3 ubiquitin transferase TRAF2|Tumor necrosis factor type 2 receptor-associated protein 3|TRAF2|TRAP3 antibody
货号:FNab10115反应性:Human, Mouse, Rat
宿主:Rabbit验证实验:ELISA, WB, IF, IHC
克隆性:polyclonal亚型:IgG
¥1900
规格:
货期: 三个工作日+顺丰快递时长
  • 产品介绍
  • 相关文献
  • 实验结果
  • 实验条件
产品名称
TRAF2 antibody
货号
FNab10115
规格
100μg
状态
liquid
纯化方法
Immunogen affinity purified
纯度
≥95% as determined by SDS-PAGE
克隆性
polyclonal
亚型
IgG
存储
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
免疫原信息
免疫原
TNF receptor-associated factor 2
别称
TNF receptor-associated factor 2|E3 ubiquitin-protein ligase TRAF2|RING-type E3 ubiquitin transferase TRAF2|Tumor necrosis factor type 2 receptor-associated protein 3|TRAF2|TRAP3 antibody
UniProt ID
Q12933
分子量
54 kDa
验证实验
验证实验
ELISA, WB, IF, IHC
建议稀释比例
WB: 1:500-1:2000; IHC: 1:50-1:500; IF: 1:50-1:500
验证图片
HeLa cells were subjected to SDS PAGE followed by western blot with FNab10115 (TRAF2 antibody) at dilution of 1:1000
Immunohistochemical analysis of paraffin-embedded human liver cancer tissue slide using FNab10115( TRAF2 Antibody) at dilution of 1:200
背景介绍
The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from members of the TNF receptor superfamily. This protein directly interacts with TNF receptors, and forms a heterodimeric complex with TRAF1. This protein is required for TNF-alpha-mediated activation of MAPK8/JNK and NF-kappaB. The protein complex formed by this protein and TRAF1 interacts with the inhibitor-of-apoptosis proteins (IAPs), and functions as a mediator of the anti-apoptotic signals from TNF receptors. The interaction of this protein with TRADD, a TNF receptor associated apoptotic signal transducer, ensures the recruitment of IAPs for the direct inhibition of caspase activation. BIRC2/c-IAP1, an apoptosis inhibitor possessing ubiquitin ligase activity, can unbiquitinate and induce the degradation of this protein, and thus potentiate TNF-induced apoptosis. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of only one transcript has been determined.